<p class="p"><span style="font-family: 'Times New Roman';">The tumor microenvironment (TME) is a highly complex ecosystem where cancer cells, immune cells, and metabolites constantly interact, ultimately dictating the success or failure of anti-tumor immunity.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">As tumors progress, they create a harsh, metabolically challenging environment. The severe depletion of nutrients, coupled with the accumulation of immunosuppressive metabolites and altered signaling, puts immense pressure on immune cells. This metabolic stress is a primary driver of T cell dysfunction and immune evasion, severely limiting the effectiveness of current cancer immunotherapies.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">To help researchers navigate and overcome these challenges, Creative Biolabs invites you to an exclusive, free webinar led by renowned immunology expert Greg M. Delgoffe, Ph.D.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Webinar Details</span>

<p class="p"><span style="font-family: 'Times New Roman';">Topic: Modeling T Cell Dysfunction in Tumor Microenvironments</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Date & Time: September 1, 2026 | 10:00 AM EDT</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Featured Speaker: Greg M. Delgoffe, Ph.D. (Professor of Immunology, University of Pittsburgh; Associate Director for Basic Research & Director of the Tumor Microenvironment Center at the UPMC Hillman Cancer Center)</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Why You Should Attend</span>

<p class="p"><span style="font-family: 'Times New Roman';">Traditional models often fail to capture the intricate crosstalk between tumor metabolism and immune regulation. Understanding these metabolic conditions is absolutely critical for developing next-generation therapeutic strategies.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">In this session, Dr. Delgoffe will explore advanced approaches for modeling the TME in preclinical research systems. From metabolically distinct tumor models to defined immunologic stress conditions, you will discover how these cutting-edge models provide physiologically relevant environments to investigate T cell dysfunction and therapeutic responses.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Key Learning Objectives:</span>

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<p class="p"><span style="font-family: 'Times New Roman';">The Metabolic Toll: How tumor metabolic environments contribute to immune suppression and T cell dysfunction.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Preclinical Strategies: Advanced methods for accurately modeling TME conditions in preclinical research systems.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Immune Evasion: How metabolically distinct tumors reveal hidden mechanisms of immune escape.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">T Cell Biology: The specific impacts of nutrient depletion and toxic metabolic byproducts on T cell function and exhaustion.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Translational Opportunities: How novel insights into immunometabolism can guide the development and enhancement of next-generation cancer immunotherapies.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Who Should Attend?</span>

<p class="p"><span style="font-family: 'Times New Roman';">Cancer Immunologists studying tumor immunity and immune suppression mechanisms.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Scientists & Researchers focused on immunotherapy, T cell biology, and immunometabolism.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">R&D Professionals in pharma and biotech involved in oncology drug discovery and immune checkpoint therapies.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Translational Researchers seeking advanced preclinical models to better understand immune-tumor interactions.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Secure Your Spot Today!</span>

<p class="p"><span style="font-family: 'Times New Roman';">Don't miss this opportunity to gain actionable insights from a leading expert in immunometabolism and TME research.</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Click the link below to register for free:Register Now: Modeling T Cell Dysfunction in Tumor Microenvironments</span>

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<p class="p"><span style="font-family: 'Times New Roman';">Spaces are limited. Register early to ensure your access to the live session and Q&A!</span>